Lafora research paper is in the top 3 most cited papers of 2018
Our paper, Nationwide genetic testing towards eliminating Lafora disease from Miniature Wirehaired Dachshunds in the United Kingdom, published in Canine Genetics and Epidemiology is in the top 3 articles that have received the most citations in the journal since the beginning of 2018, according to Clarivate's Web of Science. Citations serve as a marker of interest from the research community, but are not the only way of evaluating an article's significance.
3 members of the Breed Council's Health Committee (Ian Seath, Gill Key, Sue Holt) were co-authors, along with Saija Ahonen, Clare Rusbridge, Travis Wang, Peixiang Wang & Berge A. Minassian.
This study provides valuable data for the MWHD community and shows that the DNA test is a useful tool for the breeders to prevent occurrence of Lafora disease in MWHDs. DNA testing has, over 6 years, helped to decrease the frequency of carriers and dogs at risk. Additionally, the DNA test can continue to be used to slowly eradicate the disease-causing mutation in the breed. However, this should be done carefully, over time, to avoid further compromising the genetic diversity of the breed. The DNA test also provides a diagnostic tool for veterinarians if they are presented with a dog that shows clinical signs associated with canine Lafora disease.
The Lafora project was led by the Wirehaired Dachshund Club. Screening sessions were managed by a small team including Sue Holt, Nora Price and Mandy Dance. Anne Moore is now Secretary of the Club and she, or Mandy Dance (Chairman) can provide information and advice on Lafora screening.