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Understanding the genetics of Disc Disease (IVDD) - UC Davis 2017

University of California, Davis, researchers have revealed the discovery of a genetic mutation across breeds that is responsible for chondrodystrophy (the skeletal disorder leading to shorter legs and abnormal intervertebral discs) in a study published in the Proceedings of the National Academy of Sciences. [UCD Press Release]

The paper says there are two FGF4 retrogenes on chromosomes 12 and 18. The one on 18 causes dwarfism (CDPA), the one on 12 is associated with dwarfism and IVDD (CDDY). The paper suggests 100% of Dachshunds are homozygous for the 18 ve